Human Growth Hormone
Human Growth Hormone (GH)
Active-Life: Varies Upon Injection Method
Drug Class: Growth Hormone/IGF-1 Precursor (for injection)
Average reported dosages 2-16iu's total daily (1mg=2.7iu)
High BLood Pressure: Rare
Liver Toxicity: None
Highly Anabolic/No Androgenic
Human Growth Hormone (GH) has been a subject of debate since I was a kid. Natural(endogenous) GH is produced by the Pituitary Gland. Children produce 2 i.u. spurts 4-7 times a day for 4-5 non consecutive days during a three week period (during growth spurts). That would equal 32-70 i.u. in only a 4-5 day period. A healthy adults pituitary releases only 0.5-1.5i.u's daily.
Until the mid 1980's, the only available form of exogenuos(occuring outside the body) GH was manufactured from dead corpses by grinding them up.No Joke here. The GH was then extracted and purified through expensive procedures, packed and sold by script only for use by children sufferring from stunted growth. About 1987, this form of GH was linked to a fatal brain disease called Creutzfeld-Jakob disease and removed from the market.
Enter Genetech and Synthetic GH. The first synthetic GH was produced by genetically altering transformed mouse cells/Ecoli. Natural GH has 191 amino acids in it's sequence where as the Protropin brand of GH produced by Genetech contains 192 amino acids in it's sequence. This may have the affect of causing the body to produce GH antibodies which deactivate GH. Most synthetics now contain the normal 191 amino acid sequence, of which there are over a dozen available today.
GH has 3 effects which any athletes desires: GH helps the body burn more adipose (fat) tissue by promoting the release of fatty acids to be used as energy. Normally at rest, ther body uses about an equal division of fat and carbohydrate calories. When the endocrine system senses a low circulatory level of glucose, the hypothalamus-pituitary-axis (HPA) reacts by releasing GH . The GH then triggers(through a series of enzymatic/chemical reactions) the release of fatty acids from adipose stores so metabolic energy requirements can be met.This means that exogenous GH administration has been well documented to do the same.
GH has a very potent anabolic (protein synthesis/tissue building) effect. In exerting anabolic effects, it can cause both hyperplasia (an increase in the number of muscle cells), and muscular hypertrophy (the enlargement of muscle cells). This change in cell number is permanent and therefore means more cells to make bigger. GH also has as an anabolic effect in soft tissues, cartilage,tendons and other connective tissue...both at an accelerated rate. It is a well known fact that GH is a powerful anti-catabolic agent(protein sparing). This effect has allowed modern bodybuilders to retain or even add mass during calorie restricted periods.
When using GH many athletes were less than satisfied with their results due to bogus GH. To test GH most simply bought a pregnancy test kit mix a vial of gh and add a drop or two to the test area. If the test result= pregnant they had been screwed. Most kits test for elevated gonadoltropins which HCG is and GH is not. For those few who develop GH antibodies GH won't work for you.
GH itself is not responsible for the majority of it's effects seen. Actually GH is a precursor to the "good stuff". When GH passes through the liver it is converted to Insulin-Like Growth Factors such as IGF-1. IGF-1 is a very active but unstable chemical, which is why the body waits until the last second to make it naturally.The Liver has the limited ability to convert excess GH into IGF-1 unless other hormones are elevated. Insulin,T-4/T-3 thyroid hormones,gonadotropins androgens/anabolics hormones estrogen and corticosteroids all play an important role in the positive effects of GH. So they too were often exogenously elevated in what was considered the correct ratios by the largest of self administering athletes. For the liver to convert high levels of GH to IGF-1 several times a day and cause a high quality anabolic response, it was commonly noted that T-3 thyroid hormone and insulin also be needed to be increased to accomplish the deired effect. Triacana may be strong enough to increase thyroid activity,but cytomel was considered a better choice. Though some seemed to disagree, most believed that a fast acting insulin such as Humulin-R Or Humalog was a better, safer choice of exogenous insulin since they allowed better timing and have a much shorter effective period. This allowed athletes to time insulin activity with the active period of GH at the optimum absorption time such as waking and the first few hours after a workout. The result was less of a chance of fat accumulation and a heightened anabolic response. Since GH surpresses natural T-3 thyroid hormone release, the administration of cytomel or Triacana allows for an elevated calorie intakethat is utilized more for building muscle and soft tissue than adiptose tissue storage. Many pro bodybuilders use Clenbuterol and ephedrine stacks with GH while dieting. Since Clen. and Ephedrine surpress natural insulin release, they usually stacked the GH and Clen/Ephedrine with a T-3 thyroid hormone and sometimes with Insulin. The use of insulin is dependant on whether it is a bulking or dieting phase and dependant how their body reacted to exogenous insulin use.
AAS and or Clen further enhance the anabolic effect GH. From all but a few polled it was reported that excellent muscle mass gains resulted with GH when other Hormone levels were also met.
Dosage is a big question. GH for stunted growth is prescribed .3 i.u. per lb of bodyweight weekly. So for a bb'er weighing 235lbs that would equal 70 i.u. per week (10 i.u. per day) However 2-3 i.u. can produce nice results over 6-8 week period. when other hormone requirements are met. Short high dose burst cycles too were noted to create good results for elite bodybuilders.
With exception of those few who state otherwise dry unmixed GH substance may be stored at room temperature. Once the solution is mixed with the GH powder (swirled not shaken!) the mixture must be refrigerated for 24 hours befor it begins to degrade. Depo-Nutropin has an active life of about a month. This would allow for fewe injections and a reduced price.As patents run out many overseas GH preparations will be available in the US at a reduced price.
When GH was used with an insulin protocolit is considered important to space injections periods between gh and insulin about an hour. Also if GH was used twice daily it was reported to avoid natural high points of GH release such as first thing in the am post work-out and before bed. This is if GH was utilized without insulin.
Literature lists side effects as kidney and heart enlargements , high BP and diabetes thyroid hormone deficiency and acromegaly. These are rare and can result from extreme dosages and length of cycles.