When I was in my 20's I tried mk677 a couple times and it was absolutely awful. I had all the side effects, no benefit. Because I'm stupid, I'm actually on mk677 currently and it's completely different. Using 12.5mg on an empty stomach in the morning, I have some edema in my legs which isn't noticeable besides when I wear a pair of slacks at work that don't have any flexibility in the legs, and I get the hunger a few hours after taking the MK677 but absolutely nothing like it was when I was in my 20s. I've gained 13 pounds this months and to me I look alot better in the mirror which is the entire point...so I'll probably turn this into a 6 month run of MK.