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Old 03-28-2010, 10:07 PM
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Default Proviron

Proviron
Mesterolone

Proviron (mesterolone) is basically an orally active DHT (Dihydrotestosterone) preparation. For comparision, we can think of some other orally prepared DHT compounds like Winstrol, Anavar, etc& Those both act very similarly in mechanism to Proviron, but a more accurate way to think of this compound is as something like "Oral Masteron." As Iīm sure you noticed, their anabolic/androgenic ratio is very similar.Remember, DHT is 3 to 4 times as androgenic as testosterone and is, of course, incapable of forming estrogen. Also, Proviron is quite unique in that a simple look at itīs 4-ring structure will show us that it is not going to be too liver toxic, since it is not c17-Alpha-Alkylated, as many orals are& this modification (lacking in Proviron) makes drugs more liver toxic. Proviron has a 1-metyhl group added, instead. Looks pretty great on paper, right? Well, as usual, things tend to look better on paper than they do in the body. Your body has a negative feedback loop which prevents your body from having too much DHT floating around(if youīve been paying attention up to now from reading my other stuff, you already know this). An excess of DHT will eventually be changed into another (largely not anabolic) compound.

And of course, being a DHT-based compound, this stuff isnīt going to be great for female athletes to use. Virilization (development of male sexual characteristics) is going to be a concern for women daring enough to try this stuff. My advice is that there is much better, safer compounds for female athletes and bodybuilders to use.

So lets go back to the comparison with being some sort of "Oral Masteron"& basically since Proviron is 5-alpha reduced and not capable of forming estrogen, and also has a very high affinity for binding to the aromatase enzyme (the enzyme responsible for converting all that good testosterone in your body into all that nasty estrogen). That means if you choose to take proviron with testosterone (and I know you wouldnīt even be doing a cycle without including some form of testosterone) and/or any aromatizable steroid, it should actually serve to prevent estrogen build up by the aforementioned binding to the aromatase enzyme, which prevents aromatase from doing itīs dirty work and making a bunch of estrogen out of the other steroids you are taking. It should also be noted that Proviron also binds very well to SHBG (Sex Hormone Binding Globulin& a hormone responsible for reducing the amount of circulating free testosterone in your body)(1). As a matter of fact, in the last study I read, it bound to SHBG better than any other drug studied. Also, Iīd like to note that Proviron bound to the Anabolic Receptor better than any oral anabolic (except for the insanely toxic MethylTrienolone), having an ability to bind to the AR better then testosterone, but not as well as Nandrolone (1). Unfortunately, as we know, DHT also has a high affinity for binding to receptors in the scalp and prostate, causing some possible nasty side effects, like male pattern baldness and prostate enlargement. Itīs important to remember that DHT and DHT derived compounds are used quite successfully to treat gynocomastia, and in this area, Proviron is no different.

Letīs delve into some of the positive points of this drug before we go any farther. Androgen Receptors are found in fat cells as well as muscle cells(5), and whilethey act on the AR in muscle cells to promote growth, they also act directly on the AR in fat cells to affect fat burning.(9)(3) The stronger the androgen binds to the A.R, the higher the lipolytic (fat burning) effect on adipose (fat)tissue(6)(2). As if thatīs not enough good news, some steroids (notably, testosterone) even increase the numbers of A.R. in muscle and fat (9)(7). Thus, if you are taking a simple stack of proviron and testosterone, youīll have more of the test you shoot as free testosterone floating around building muscle (compliments of the Proviron), more androgen receptors to be bound to (compliments of your testosterone) by your Proviron, thus causing more fat loss. Testosterone and Proviron are a very nice synergistic stack, pretty nearly an "ideal" stack of an oral and injectable, because both drugs will actually act to enhance the effect of the other.

So what we have here is a steroid which can basically make other steroids more effective by preventing their conversion into estrogen, as well as increasing the amount of circulating free testosterone in your body. This of course all provides a more hardened and quality look to muscles. Proviron is very much a "synergistic" drug in this respect, and itīs inclusion in any cycle would definitely make all of the other steroids perform better, and provide better gains. This is all compounded by the fact that proviron is a very lipolytic (fat-burning) drug.

Now, as if all of this werenīt enough, letīs talk about how Proviron affects your HPTA (Hypothalamic-Pituitary-Testicular-Axis)& the thing that regulates the male hormonal system. When a reasonable dose of this stuff is given (100-150mgs/day), it had no depressing effect on low or normal serum FSH and LH levels (6). Follicle Stimulating Hormone (FSH) and Leutenizing Hormone (LH) are two hormones which send a signal to your testes to produce testosterone. Good news for people considering it for PCT is that it can even raise your LH (10)! Thus, by not suppressing those hormones and maybe even raising some, your normal testosterone levels will remain intact. This points to a novel use for this compound during Post-Cycyle-Therapy for a non-suppressive "bridge" between cycles. In fact, in yet another study, administration of Proviron (basically the same dose as in the last study) produced no changes in steroids, thyroid hormones, gonadotropins nor PRL (Prolactin Levels& you want those to remain low). (8).

Unfortunately, this stuff is not too hot on itīs own. Itīs a good drug for inclusion in a cycle containing testosterone and other armoatizable steroids, and itīs a good drug for a possible "bridge" between cycles. Alone, however, as an androgenic or anabolic agent, itīs effects have been very weak in both studies (9), as well as in the experience of everyone I spoke to about it. This may be due to the addition of the 1-methyl-group to DHT, which makes this stuff orally active. Whatever the case, as a stand alone anabolic or androgenic compound, itīs not too impressive.

This drug is a rare find on the American Black Market, and many Underground Labs donīt even produce it, but if you can find it, Iīd say that you shouldnīt be paying more than .50cents for each 50mg tab.
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Old 04-17-2010, 08:02 PM
The Ringer The Ringer is offline
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Where is this taken from, I see studies (I am assuming) cited and would like to did into the effect on HPTA suggested during PCT.

"it had no depressing effect on low or normal serum FSH and LH levels (6). "--- I also would like to see where this was taken.

Thanks
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Old 04-18-2010, 11:36 AM
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Quote:
Originally Posted by The Ringer View Post
Where is this taken from, I see studies (I am assuming) cited and would like to did into the effect on HPTA suggested during PCT.

"it had no depressing effect on low or normal serum FSH and LH levels (6). "--- I also would like to see where this was taken.

Thanks
it was from steroid.com. i think in the profile section. i know there is one here, but this one was written a little different.
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Old 02-28-2013, 04:03 PM
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Quote:
Originally Posted by terrypark View Post
This drug is a rare find on the American Black Market, and many Underground Labs donīt even produce it, but if you can find it, Iīd say that you shouldnīt be paying more than .50cents for each 50mg tab.
I wish I could find that price. PM me if you know of any.
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Old 03-03-2013, 06:41 PM
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Team Superman ...
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Old 03-25-2013, 02:05 PM
msc173 msc173 is offline
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I know its stated in the article that its good to take with testosterone, but what about with tren e, eq, and masteron? That is the current cycle im running preparing for a competition
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Old 03-26-2013, 12:08 PM
stickfigure71 stickfigure71 is offline
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yeah i was considering 25 mgs proviron during clomid/nolva PCT but i heard so many differing opinions that it seemed like it could be counterproductive. I am not planning on doing another cycle for at least 6 or so months, so i really wouldn't need a bridge.
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Old 03-27-2013, 12:55 PM
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Big fan of Proviron, If I have it I use it all the time, I don't recommend it with PCT, some have used it and was fine but IMO it will slow recovery because if taken alone it will shut you down.
I love the stuff when cutting and using Tren, .....................11
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Old 03-28-2013, 08:46 PM
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Proviron is great to take with anything other than masteron ....i guess u can even take it with that but it seems like overkill
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Old 04-30-2013, 02:28 PM
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I use proviron in all of my cycles. It adds some hardness and helps with erections.
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Old 02-26-2014, 11:56 PM
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How well would it be running with Cut Stack? And if so at what dose?
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Old 02-27-2014, 06:54 AM
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I do 50mg of proviron non-stop.NOTHING gives me a harder and much fuller look....
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Old 02-27-2014, 07:59 AM
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I do 50mg of proviron non-stop.NOTHING gives me a harder and much fuller look....
I do too. Been experimenting with 150mg a day.
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Old 02-27-2014, 09:13 AM
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I do too. Been experimenting with 150mg a day.
How long have you been running it and what have you noticed ?
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Old 02-28-2014, 08:31 AM
BUSHMASTER BUSHMASTER is offline
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How long have you been running it and what have you noticed ?
Just upped it to 150mg a few weeks ago. Increased well being, libido and definitely see some recomp changes.
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Old 02-28-2014, 08:41 AM
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I run proviron year round at 25 mg a day sometimes ill go up to 50 or 75mg if I can afford it.I love the stuff
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Old 03-02-2014, 02:03 AM
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i actually started taking it for the first time ever like a week ago and I already see a huge difference in leanness
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Old 03-03-2014, 12:21 AM
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Originally Posted by Nschneider72 View Post
How well would it be running with Cut Stack? And if so at what dose?
Like peanut butter and jelly. And run as much and as long as u can afford.

I ALWAYS run proviron...100mg is magic.
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Old 03-03-2014, 09:09 AM
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Are there any negatives and is it hard on liver or kidneys?
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Old 03-05-2014, 11:17 AM
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Are there any negatives and is it hard on liver or kidneys?
NO to both. It is NOT liver toxic .................11
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Old 03-05-2014, 10:18 PM
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Thanks brutha!! Placing my order Thursday!0
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Old 03-20-2014, 07:37 PM
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If running just a basic test cycle with some dbol, would proviron be a suitable or even better choice/replacement for arimidex as far as estrogen control, and could a switch be made early cycle? No to mention it enhancing test?
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Old 03-21-2014, 04:31 PM
CABO JO CABO JO is offline
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If running just a basic test cycle with some dbol, would proviron be a suitable or even better choice/replacement for arimidex as far as estrogen control, and could a switch be made early cycle? No to mention it enhancing test?
wouldn't rely on proviron to replace adex,not a good idea imo
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Old 04-23-2014, 09:07 AM
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If running just a basic test cycle with some dbol, would proviron be a suitable or even better choice/replacement for arimidex as far as estrogen control, and could a switch be made early cycle? No to mention it enhancing test?
Listen brother, everybody responds differently and only blood tests would know for sure if your plan would work. Most likely you would still need an ancillary. I find that on 200/wk (TRT) proviron does the job well enough, but any more testo than that and I have to add in aromasin a couple times per week.

Its really a matter of trial and error, which is exactly what my TRT doc does as well. They try it, then take blood, adjust and test again. That's the game.
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Old 04-23-2014, 10:32 AM
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Proviron is great to free up more test and I use it all the time but u def need an ati estrogen with a test cycle.my choice is aromasin
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